A sexually transmitted virus, affecting almost two-thirds of people worldwide, could be linked to dementia according to a recent study. 

Researchers from the University of Illinois Chicago have issued a serious warning after studying herpes simplex virus type one (HSV-1), which they discovered can also infect the nasal cavity.

Herpes, as it’s commonly known, leads to painful sores or ulcers. It mainly spreads through direct skin contact and, while it can be treated, it cannot be completely cured.

 

HSV-1, more commonly known as herpes, infects almost two-thirds of the world populationGetty stock
The World Health Organization (WHO) highlights that there are two main types of this virus. Type one, which typically spreads through oral contact, leads to infections around the mouth. 

“It can also cause genital herpes. Most adults are infected with HSV-1,” according to WHO.

Type two, on the other hand, is sexually transmitted and is the cause of genital herpes.

Experts are now noting that HSV-1 can also be passed through oral sex in some cases. 

“If an infected individual is shedding virus via tears, it could reach the nasal cavity, where it could go more directly to the brain,” said Dr. Deepak Shukla, the study’s lead author.

“I think it’s underdiagnosed and understudied, but the neurological consequences, we believe, are much more severe than you would normally see with fever blisters or ocular infection.”

 

HSV-1 is a lifelong infection that can be treated but not curedGetty stock
In experiments with lab mice, researchers found that a protein called heparanase makes HSV-1-related conditions worse, contributing to brain swelling and behavioral issues. 

When mice were infected with HSV-1 through their noses, the protein triggered inflammation in their brains. This led to memory loss, increased anxiety, and trouble with movement

Interestingly, mice that lacked this protein had fewer of these complications.

As the study, published recently in mBio, explains: “Our findings position HPSE as a potential therapeutic target for mitigating virus-induced neuroinflammation and neurobehavioral defects.” 

“There is definitely nerve damage if you take the intranasal route, and the effects are long-term, which is alarming,” added Shukla.

Hemant Borase, a postdoctoral researcher at the University of Illinois Chicago and the study’s first author, also shared: “These insights open the door to potential therapeutic approaches to mitigate the effects of neuroinflammation and prevent long-term brain injury caused by viral infections.”

 

HSV-1 located in or around the nose may lead to dementia, according to the studyGetty stock
Chandrashekhar Patil, another co-author and research assistant professor at the College of Medicine, shared additional thoughts. 

“The virus reactivates throughout life; it’s a lifelong infection.”

“So, I think this awareness will be really important among the large population which is carrying this virus.”

That being said, it’s important to remember that cases where the infection reaches the brain are extremely rare.

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